A New Approach to Producing Functional Gα Subunits Yields the Activated and Deactivated Structures of Gα(12/13) Proteins

The oncogenic G(12/13) subfamily of heterotrimeric G proteins transduces extracellular signals that regulate the actin cytoskeleton, cell cycle progression, and gene transcription. Previously, structural analyses of fully-functional Gα(12/13) subunits have been hindered by insufficient amounts of ho...

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Bibliographic Details
Main Authors:	Kreutz, Barry, Yau, Douglas M., Nance, Mark, Tanabe, Shihori, Tesmer, John J. G., Kozasa, Tohru
Format:	Artigo
Language:	Inglês
Published:	2006
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2688741/ https://ncbi.nlm.nih.gov/pubmed/16388592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051729t
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A New Approach to Producing Functional Gα Subunits Yields the Activated and Deactivated Structures of Gα(12/13) Proteins

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