Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gα(q) Complex

The heterotrimeric G protein Gα(q) is a key regulator of blood pressure, and excess Gα(q) signaling leads to hypertension. A specific inhibitor of Gα(q) is the GTPase activating protein (GAP) known as regulator of G protein signaling 2 (RGS2). The molecular basis for how Gα(q/11) subunits serve as s...

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Main Authors: Nance, Mark R., Kreutz, Barry, Tesmer, Valerie M., Sterne-Marr, Rachel, Kozasa, Tohru, Tesmer, John J.G.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638996/
https://ncbi.nlm.nih.gov/pubmed/23434405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.12.016
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