Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection....

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Main Authors: von Bernuth, Horst, Picard, Capucine, Jin, Zhongbo, Pankla, Rungnapa, Xiao, Hui, Ku, Cheng-Lung, Chrabieh, Maya, Mustapha, Imen Ben, Ghandil, Pegah, Camcioglu, Yildiz, Vasconcelos, Júlia, Sirvent, Nicolas, Guedes, Margarida, Vitor, Artur Bonito, Herrero-Mata, María José, Aróstegui, Juan Ignacio, Rodrigo, Carlos, Alsina, Laia, Ruiz-Ortiz, Estibaliz, Juan, Manel, Fortuny, Claudia, Yagüe, Jordi, Antón, Jordi, Pascal, Mariona, Chang, Huey-Hsuan, Janniere, Lucile, Rose, Yoann, Garty, Ben-Zion, Chapel, Helen, Issekutz, Andrew, Maródi, László, Rodriguez-Gallego, Carlos, Banchereau, Jacques, Abel, Laurent, Li, Xiaoxia, Chaussabel, Damien, Puel, Anne, Casanova1, Jean-Laurent
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688396/
https://ncbi.nlm.nih.gov/pubmed/18669862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1158298
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