Lipid Rafts and Clathrin Cooperate in the Internalization of PrP(C) in Epithelial FRT Cells

BACKGROUND: The cellular prion protein (PrP(C)) plays a key role in the pathogenesis of Transmissible Spongiform Encephalopathies in which the protein undergoes post-translational conversion to the infectious form (PrP(Sc)). Although endocytosis appears to be required for this conversion, the mechan...

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Main Authors: Sarnataro, Daniela, Caputo, Anna, Casanova, Philippe, Puri, Claudia, Paladino, Simona, Tivodar, Simona S., Campana, Vincenza, Tacchetti, Carlo, Zurzolo, Chiara
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688078/
https://ncbi.nlm.nih.gov/pubmed/19503793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005829
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