Replication-Defective Adenovirus Vectors with Multiple Deletions Do Not Induce Measurable Vector-Specific T Cells in Human Trials

The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells were determined in volunteers with and without preexisting neutralizing antibodies (NAs) to Ad5 who received replication-defective Ad5 (rAd5)-based human immunodeficiency virus vaccines. There was no correlation between T-ce...

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Autores principales: Koup, Richard A., Lamoreaux, Laurie, Zarkowsky, David, Bailer, Robert T., King, C. Richter, Gall, Jason G. D., Brough, Douglas E., Graham, Barney S., Roederer, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687372/
https://ncbi.nlm.nih.gov/pubmed/19339347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00384-09
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