Identification of a Suppressor Mutation That Improves the Yields of Hexon-Modified Adenovirus Vectors

We have generated hexon-modified adenovirus serotype 5 (Ad5) vectors that are not neutralized by Ad5-specific neutralizing antibodies in mice. These vectors are attractive for the advancement of vaccine products because of their potential for inducing robust antigen-specific immune responses in peop...

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Detalhes bibliográficos
Main Authors: Bruder, Joseph T., Chen, Ping, Semenova, Elena, Thomas, Charlie A., Konovalova, Svetlana, Ekberg, Greg, Ettyreddy, Damodar, McVey, Duncan, Gall, Jason G., King, C. Richter, Brough, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754123/
https://ncbi.nlm.nih.gov/pubmed/23824800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00462-13
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