Identification of a Suppressor Mutation That Improves the Yields of Hexon-Modified Adenovirus Vectors

We have generated hexon-modified adenovirus serotype 5 (Ad5) vectors that are not neutralized by Ad5-specific neutralizing antibodies in mice. These vectors are attractive for the advancement of vaccine products because of their potential for inducing robust antigen-specific immune responses in peop...

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Autori principali: Bruder, Joseph T., Chen, Ping, Semenova, Elena, Thomas, Charlie A., Konovalova, Svetlana, Ekberg, Greg, Ettyreddy, Damodar, McVey, Duncan, Gall, Jason G., King, C. Richter, Brough, Douglas E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754123/
https://ncbi.nlm.nih.gov/pubmed/23824800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00462-13
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