Inactivation of the Glycoside Hydrolase NagZ Attenuates Antipseudomonal β-Lactam Resistance in Pseudomonas aeruginosa

The overproduction of chromosomal AmpC β-lactamase poses a serious challenge to the successful treatment of Pseudomonas aeruginosa infections with β-lactam antibiotics. The induction of ampC expression by β-lactams is mediated by the disruption of peptidoglycan (PG) recycling and the accumulation of...

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Bibliographic Details
Main Authors: Asgarali, Azizah, Stubbs, Keith A., Oliver, Antonio, Vocadlo, David J., Mark, Brian L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687237/
https://ncbi.nlm.nih.gov/pubmed/19273679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01617-08
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