The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

The increasing incidence of inducible chromosomal AmpC β-lactamases within the clinic is a growing concern because these enzymes deactivate a broad range of even the most recently developed β-lactam antibiotics. As a result, new strategies are needed to block the action of this antibiotic resistance...

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Main Authors: Stubbs, Keith A, Bacik, John-Paul, Perley-Robertson, G Evan, Whitworth, Garrett E, Gloster, Tracey M, Vocadlo, David J, Mark, Brian L
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920638/
https://ncbi.nlm.nih.gov/pubmed/24009110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300395
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