R964C Mutation of DNA Polymerase γ Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity

The R964C mutation of human DNA polymerase γ was recently linked to stavudine (d4T)-mediated mitochondrial toxicity. We utilized pre-steady-state kinetics to determine the effect of this mutation on incorporation of natural substrate dTTP and the active metabolite of d4T (d4TTP). The R964C polymeras...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Bailey, Christopher M., Kasiviswanathan, Rajesh, Copeland, William C., Anderson, Karen S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687208/
https://ncbi.nlm.nih.gov/pubmed/19364868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01659-08
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky