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R964C Mutation of DNA Polymerase γ Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity

The R964C mutation of human DNA polymerase γ was recently linked to stavudine (d4T)-mediated mitochondrial toxicity. We utilized pre-steady-state kinetics to determine the effect of this mutation on incorporation of natural substrate dTTP and the active metabolite of d4T (d4TTP). The R964C polymeras...

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Detalhes bibliográficos
Main Authors: Bailey, Christopher M., Kasiviswanathan, Rajesh, Copeland, William C., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687208/
https://ncbi.nlm.nih.gov/pubmed/19364868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01659-08
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