Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear to be proteolytically released by members of the ADAM family of metalloproteases. Because membrane-anchored EGFR ligands are thought to be biologically active, the role of li...

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Main Authors: Dong, Jianying, Opresko, Lee K., Dempsey, Peter J., Lauffenburger, Douglas A., Coffey, Robert J., Wiley, H. Steven
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC26865/
https://ncbi.nlm.nih.gov/pubmed/10339571
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