The Membrane-anchoring Domain of Epidermal Growth Factor Receptor Ligands Dictates Their Ability to Operate in Juxtacrine Mode

All ligands of the epidermal growth factor (EGF) receptor (EGFR) are synthesized as membrane-anchored precursors. Previous work has suggested that some ligands, such as EGF, must be proteolytically released to be active, whereas others, such as heparin-binding EGF-like growth factor (HB-EGF) can fun...

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Bibliographic Details
Main Authors: Dong, Jianying, Opresko, Lee K., Chrisler, William, Orr, Galya, Quesenberry, Ryan D., Lauffenburger, Douglas A., Wiley, H. Steven
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2005
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142441/
https://ncbi.nlm.nih.gov/pubmed/15829568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-11-0994
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