Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization

Autocrine EGF-receptor (EGFR) ligands are normally made as membrane-anchored precursors that are proteolytically processed to yield mature, soluble peptides. To explore the function of the membrane-anchoring domain of EGF, we expressed artificial EGF genes either with or without this structure in hu...

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Autors principals: Wiley, H. Steven, Woolf, Margaret F., Opresko, Lee K., Burke, Patrick M., Will, Birgit, Morgan, Jeffrey R., Lauffenburger, Douglas A.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1998
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133076/
https://ncbi.nlm.nih.gov/pubmed/9832559
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