Rapid and sustained nuclear–cytoplasmic ERK oscillations induced by epidermal growth factor

Although the ERK pathway has a central role in the response of cells to growth factors, its regulatory structure and dynamics are incompletely understood. To investigate ERK activation in real time, we expressed an ERK–GFP fusion protein in human mammary epithelial cells. On EGF stimulation, we obse...

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Detalhes bibliográficos
Main Authors: Shankaran, Harish, Ippolito, Danielle L, Chrisler, William B, Resat, Haluk, Bollinger, Nikki, Opresko, Lee K, Wiley, H Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824491/
https://ncbi.nlm.nih.gov/pubmed/19953086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2009.90
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