Sonic hedgehog negatively regulates pre-TCR–induced differentiation by a Gli2-dependent mechanism

Hedgehog signaling regulates differentiation, survival, and proliferation of the earliest double-negative (DN) thymocytes, but its importance at later stages of T-cell development is controversial. Here we use loss- and gain-of-function mouse models to show that Shh, by signaling directly to the dev...

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Main Authors: Rowbotham, Nicola J., Hager-Theodorides, Ariadne L., Furmanski, Anna L., Ross, Susan E., Outram, Susan V., Dessens, Johannes T., Crompton, Tessa
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2009
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686185/
https://ncbi.nlm.nih.gov/pubmed/19273836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-185751
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