Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice. Activation of Hh signaling in thymocytes in vivo by expression of a transgenic transcriptional-activato...

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Detalhes bibliográficos
Main Authors: Rowbotham, Nicola J., Hager-Theodorides, Ariadne L., Cebecauer, Marek, Shah, Divya K., Drakopoulou, Ekati, Dyson, Julian, Outram, Susan V., Crompton, Tessa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874579/
https://ncbi.nlm.nih.gov/pubmed/17227833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-037655
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