β-Selection: Abundance of TCRβ(–)/γδ(–) CD44(–)CD25(–) (DN4) cells in the foetal thymus

Expression of TCRβ and pre-TCR signalling are essential for differentiation of CD4(–)CD8(–) double negative (DN) thymocytes to the CD4(+)CD8(+) double-positive (DP) stage. Thymocyte development in adult Rag1, Rag2 or TCRβδ-deficient mice is arrested at the DN3 stage leading to the assumption that pr...

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Detalhes bibliográficos
Main Authors: Hager-Theodorides, Ariadne L, Rowbotham, Nicola J, Outram, Susan V, Dessens, Johannes T, Crompton, Tessa
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2007
Assuntos:
Molecular immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651467/
https://ncbi.nlm.nih.gov/pubmed/17273993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200636503
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