Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4+CD8+ double-positive cell

BMP2/4 signaling is required for embryogenesis and involved in thymus morphogenesis and T-lineage differentiation. In vitro experiments have shown that treatment of thymus explants with exogenous BMP4 negatively regulated differentiation of early thymocyte progenitors and the transition from CD4−CD8...

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Bibliographic Details
Main Authors: Hager-Theodorides, Ariadne L, Ross, Susan E, Sahni, Hemant, Mishina, Yuji, Furmanski, Anna L, Crompton, Tessa
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906248/
https://ncbi.nlm.nih.gov/pubmed/24240189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27118
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