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Sonic hedgehog negatively regulates pre-TCR–induced differentiation by a Gli2-dependent mechanism
Hedgehog signaling regulates differentiation, survival, and proliferation of the earliest double-negative (DN) thymocytes, but its importance at later stages of T-cell development is controversial. Here we use loss- and gain-of-function mouse models to show that Shh, by signaling directly to the dev...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2686185/ https://ncbi.nlm.nih.gov/pubmed/19273836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-185751 |
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