Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-α on Fanconi anemia hematopoietic stem and progenitor cells

Ectopic delivery of HOXB4 elicits the expansion of engrafting hematopoietic stem cells (HSCs). We hypothesized that inhibition of tumor necrosis factor-α (TNF-α) signaling may be central to the self-renewal signature of HOXB4. Because HSCs derived from Fanconi anemia (FA) knockout mice are hypersens...

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Detalhes bibliográficos
Main Authors: Milsom, Michael D., Schiedlmeier, Bernhard, Bailey, Jeff, Kim, Mi-Ok, Li, Dandan, Jansen, Michael, Ali, Abdullah Mahmood, Kirby, Michelle, Baum, Christopher, Fairbairn, Leslie J., Williams, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686182/
https://ncbi.nlm.nih.gov/pubmed/19270262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-180224
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