Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A

Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from p...

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Detalhes bibliográficos
Main Authors: Zhang, Xiaoling, Shang, Xun, Guo, Fukun, Murphy, Kim, Kirby, Michelle, Kelly, Patrick, Reeves, Lilith, Smith, Franklin O., Williams, David A., Zheng, Yi, Pang, Qishen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518878/
https://ncbi.nlm.nih.gov/pubmed/18565850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-147090
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