Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

Adhesive interactions between multiple myeloma (MM) cells and marrow stromal cells activate multiple signaling pathways including nuclear factor κB (NF-κB), p38 mitogen-activated protein kinase (MAPK), and Jun N-terminal kinase (JNK) in stromal cells, which promote tumor growth and bone destruction....

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Hlavní autoři: Hiruma, Yuko, Honjo, Tadashi, Jelinek, Diane F., Windle, Jolene J., Shin, Jaekyoon, Roodman, G. David, Kurihara, Noriyoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686139/
https://ncbi.nlm.nih.gov/pubmed/19282458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-173948
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