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Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease
Paget disease is the most exaggerated example of abnormal bone remodeling, with the primary cellular abnormality in the osteoclast. Mutations in the p62 (sequestosome 1) gene occur in one-third of patients with familial Paget disease and in a minority of patients with sporadic Paget disease, with th...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2006
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1705822/ https://ncbi.nlm.nih.gov/pubmed/17187080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28267 |
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