Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Paget disease is the most exaggerated example of abnormal bone remodeling, with the primary cellular abnormality in the osteoclast. Mutations in the p62 (sequestosome 1) gene occur in one-third of patients with familial Paget disease and in a minority of patients with sporadic Paget disease, with th...

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Detalhes bibliográficos
Main Authors: Kurihara, Noriyoshi, Hiruma, Yuko, Zhou, Hua, Subler, Mark A., Dempster, David W., Singer, Frederick R., Reddy, Sakamuri V., Gruber, Helen E., Windle, Jolene J., Roodman, G. David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1705822/
https://ncbi.nlm.nih.gov/pubmed/17187080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28267
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