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Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil

AIMS: The aim was to compare possible effects of verapamil, as a P-glycoprotein (P-gp) inhibitor, on the pharmacokinetics of each fexofenadine enantiomer, as a P-gp substrate. METHODS: Thirteen healthy Japanese volunteers (10 male and three female) were enrolled. In a randomized, two-phase, crossove...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sakugawa, Takashi, Miura, Masatomo, Hokama, Nobuo, Suzuki, Toshio, Tateishi, Tomonori, Uno, Tsukasa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686070/
https://ncbi.nlm.nih.gov/pubmed/19552748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03396.x
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