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Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

AIMS: Fexofenadine is a substrate of several drug transporters including P-glycoprotein. Our objective was to evaluate the possible effects of two P-glycoprotein inhibitors, itraconazole and diltiazem, on the pharmacokinetics of fexofenadine, a putative probe of P-glycoprotein activity in vivo, and...

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書誌詳細
主要な著者: Shimizu, Mikiko, Uno, Tsukasa, Sugawara, Kazunobu, Tateishi, Tomonori
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885063/
https://ncbi.nlm.nih.gov/pubmed/16669847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02613.x
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