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The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers

AIMS: The aim of this study was to determine the inhibitory effect of itraconazole, a P-glycoprotein (P-gp) inhibitor, on the stereoselective pharmacokinetics of fexofenadine. METHODS: A two-way double-blind, placebo-controlled crossover study was performed with a 2-week washout period. Twelve healt...

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Detalhes bibliográficos
Main Authors: Tateishi, Tomonori, Miura, Masatomo, Suzuki, Toshio, Uno, Tsukasa
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432479/
https://ncbi.nlm.nih.gov/pubmed/18294330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03116.x
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