MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

AIMS: The C3435T polymorphism in the human MDR1 gene is associated with lower intestinal P-glycoprotein expression, reduced protein function in peripheral blood cells and higher plasma concentrations of the P-glycoprotein substrate digoxin. Using fexofenadine, a known P-glycoprotein substrate, the h...

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Detalhes bibliográficos
Main Authors: Drescher, Siegfried, Schaeffeler, Elke, Hitzl, Monika, Hofmann, Ute, Schwab, Matthias, Brinkmann, Ulrich, Eichelbaum, Michel, Fromm, Martin F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874364/
https://ncbi.nlm.nih.gov/pubmed/11994059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01591.x
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