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MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine
AIMS: The C3435T polymorphism in the human MDR1 gene is associated with lower intestinal P-glycoprotein expression, reduced protein function in peripheral blood cells and higher plasma concentrations of the P-glycoprotein substrate digoxin. Using fexofenadine, a known P-glycoprotein substrate, the h...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1874364/ https://ncbi.nlm.nih.gov/pubmed/11994059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01591.x |
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