G Protein-coupled Receptor Kinase-mediated Phosphorylation Regulates Post-endocytic Trafficking of the D(2) Dopamine Receptor

We investigated the role of G protein-coupled receptor kinase (GRK)-mediated phosphorylation in agonist-induced desensitization, arrestin association, endocytosis, and intracellular trafficking of the D(2) dopamine receptor (DAR). Agonist activation of D(2) DARs results in rapid and sustained recept...

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Main Authors: Namkung, Yoon, Dipace, Concetta, Javitch, Jonathan A., Sibley, David R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685686/
https://ncbi.nlm.nih.gov/pubmed/19332542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900388200
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