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G Protein-coupled Receptor Kinase-2 Constitutively Regulates D(2) Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation

We investigated the regulatory effects of GRK2 on D(2) dopamine receptor signaling and found that this kinase inhibits both receptor expression and functional signaling in a phosphorylation-independent manner, apparently through different mechanisms. Overexpression of GRK2 was found to suppress rece...

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Detalhes bibliográficos
Main Authors: Namkung, Yoon, Dipace, Concetta, Urizar, Eneko, Javitch, Jonathan A., Sibley, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797181/
https://ncbi.nlm.nih.gov/pubmed/19815545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055707
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