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G Protein-coupled Receptor Kinase-2 Constitutively Regulates D(2) Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation

We investigated the regulatory effects of GRK2 on D(2) dopamine receptor signaling and found that this kinase inhibits both receptor expression and functional signaling in a phosphorylation-independent manner, apparently through different mechanisms. Overexpression of GRK2 was found to suppress rece...

詳細記述

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書誌詳細
主要な著者: Namkung, Yoon, Dipace, Concetta, Urizar, Eneko, Javitch, Jonathan A., Sibley, David R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797181/
https://ncbi.nlm.nih.gov/pubmed/19815545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055707
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