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G Protein-coupled Receptor Kinase-2 Constitutively Regulates D(2) Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation

We investigated the regulatory effects of GRK2 on D(2) dopamine receptor signaling and found that this kinase inhibits both receptor expression and functional signaling in a phosphorylation-independent manner, apparently through different mechanisms. Overexpression of GRK2 was found to suppress rece...

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Main Authors: Namkung, Yoon, Dipace, Concetta, Urizar, Eneko, Javitch, Jonathan A., Sibley, David R.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797181/
https://ncbi.nlm.nih.gov/pubmed/19815545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055707
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