In Vitro Analysis of Hrd1p-mediated Retrotranslocation of Its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase

Endoplasmic reticulum (ER)-associated degradation (ERAD) is responsible for the ubiquitin-mediated destruction of both misfolded and normal ER-resident proteins. ERAD substrates must be moved from the ER to the cytoplasm for ubiquitination and proteasomal destruction by a process called retrotranslo...

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Hlavní autoři: Garza, Renee M., Sato, Brian K., Hampton, Randolph Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Protein Synthesis, Post-Translational Modification, and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685653/
https://ncbi.nlm.nih.gov/pubmed/19324879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809607200
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