The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence

The tumor suppressor proteins p16(INK4A) and p14(ARF), encoded by the INK4A–ARF locus, are key regulators of cellular senescence. The locus is epigenetically silenced by the repressive H3K27me3 mark in normally growing cells, but becomes activated in response to oncogenic stress. Here, we show that...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Agger, Karl, Cloos, Paul A.C., Rudkjær, Lise, Williams, Kristine, Andersen, Gitte, Christensen, Jesper, Helin, Kristian
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2009
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685535/
https://ncbi.nlm.nih.gov/pubmed/19451217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.510809
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires