A haplotype of human angiotensinogen gene containing −217A increases blood pressure in transgenic mice compared with −217G

The human angiotensinogen (hAGT) gene contains an A/G polymorphism at −217, and frequency of −217A allele is increased in African-American hypertensive patients. The hAGT gene has seven polymorphic sites in the 1.2-kb region of its promoter, and variant −217A almost always occurs with −532T, −793A,...

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Hlavní autoři: Jain, Sudhir, Vinukonda, Govindaiah, Fiering, Steven N., Kumar, Ashok
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
Témata:
Hemodynamics and Cardiorenal Integration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685293/
https://ncbi.nlm.nih.gov/pubmed/18945948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90637.2008
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