A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression

Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron responsive element (IRE) in its 5'UTR, which ensures that its translation is repressed by iron regulatory proteins in iron-deficient conditions to maintain cellular iron content. However, here we demonstrate that du...

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Hauptverfasser: Zhang, De-Liang, Hughes, Robert M., Ollivierre-Wilson, Hayden, Ghosh, Manik C., Rouault, Tracey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685206/
https://ncbi.nlm.nih.gov/pubmed/19416716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.03.006
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