Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage

Here we define an important role for heat shock factor 1 (HSF1) in the cellular response to genotoxic agents. We demonstrate for the first time that HSF1 can complex with nuclear p53 and that both proteins are co-operatively recruited to p53-responsive genes such as p21. Analysis of natural and synt...

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Detalhes bibliográficos
Main Authors: Logan, Ian R., McNeill, Hesta V., Cook, Susan, Lu, Xiaohong, Meek, David W., Fuller-Pace, Frances V., Lunec, John, Robson, Craig N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685104/
https://ncbi.nlm.nih.gov/pubmed/19295133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp180
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