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Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage
Here we define an important role for heat shock factor 1 (HSF1) in the cellular response to genotoxic agents. We demonstrate for the first time that HSF1 can complex with nuclear p53 and that both proteins are co-operatively recruited to p53-responsive genes such as p21. Analysis of natural and synt...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685104/ https://ncbi.nlm.nih.gov/pubmed/19295133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp180 |
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