Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis

Replicative DNA polymerases possess 3′ → 5′ exonuclease activity to reduce misincorporation of incorrect nucleotides by proofreading during replication. To examine if this proofreading activity modulates DNA synthesis of damaged templates, we constructed a series of recombinant human DNA polymerase...

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Bibliographic Details
Main Authors: Fazlieva, Ruzaliya, Spittle, Cynthia S., Morrissey, Darlene, Hayashi, Harutoshi, Yan, Hong, Matsumoto, Yoshihiro
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685094/
https://ncbi.nlm.nih.gov/pubmed/19282447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp155
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