A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is expectably required for successful application in vivo. Several studies have aimed at improving siRNA perfo...

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Main Authors: Bramsen, Jesper B., Laursen, Maria B., Nielsen, Anne F., Hansen, Thomas B., Bus, Claus, Langkjær, Niels, Babu, B. Ravindra, Højland, Torben, Abramov, Mikhail, Van Aerschot, Arthur, Odadzic, Dalibor, Smicius, Romualdas, Haas, Jens, Andree, Cordula, Barman, Jharna, Wenska, Malgorzata, Srivastava, Puneet, Zhou, Chuanzheng, Honcharenko, Dmytro, Hess, Simone, Müller, Elke, Bobkov, Georgii V., Mikhailov, Sergey N., Fava, Eugenio, Meyer, Thomas F., Chattopadhyaya, Jyoti, Zerial, Marino, Engels, Joachim W., Herdewijn, Piet, Wengel, Jesper, Kjems, Jørgen
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685080/
https://ncbi.nlm.nih.gov/pubmed/19282453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp106
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