RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and downregulation of PTEN

Therapeutic inhibition of mTOR in cancer is complicated by the existence of a negative feedback loop linking mTOR to the PI3K-Akt pathway. Thus, mTOR inhibition by Rapamycin or TSC1/2 results in increased PI3K-Akt activation. The death domain kinase receptor interacting protein 1 (RIP, RIP1), plays...

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Detalhes bibliográficos
Main Authors: Park, Seongmi, Zhao, Dawen, Hatanpaa, Kimmo J., Mickey, Bruce E., Saha, Debabrata, Boothman, David A., Story, Michael D., Wong, Eric T., Burma, Sandeep, Georgescu, Maria-Magdalena, Rangnekar, Vivek M., Chauncey, Sandili S., Habib, Amyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683913/
https://ncbi.nlm.nih.gov/pubmed/19435890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0474
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