Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo

The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). We found recently that this enzyme is dramatically up-regulated in a variety of established human carcinoma cell lines and in human cancerous tissue and promotes the neoplastic...

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Bibliografiske detaljer
Main Authors: Chen, Chen, Li, Guiling, Liao, Wanmin, Wu, Jun, Liu, Liu, Ma, Ding, Zhou, Jianfeng, Elbekai, Reem H., Edin, Matthew L., Zeldin, Darryl C., Wang, Dao Wen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Pharmacology and Experimental Therapeutics 2009
Fag:
Chemotherapy, Antibiotics, and Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683771/
https://ncbi.nlm.nih.gov/pubmed/19289568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152017
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