Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo

The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). We found recently that this enzyme is dramatically up-regulated in a variety of established human carcinoma cell lines and in human cancerous tissue and promotes the neoplastic...

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Detalhes bibliográficos
Main Authors: Chen, Chen, Li, Guiling, Liao, Wanmin, Wu, Jun, Liu, Liu, Ma, Ding, Zhou, Jianfeng, Elbekai, Reem H., Edin, Matthew L., Zeldin, Darryl C., Wang, Dao Wen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683771/
https://ncbi.nlm.nih.gov/pubmed/19289568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152017
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