Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways. We exploit experimental and computational approaches to reveal how a concordant interplay between the insulin and epidermal growth factor (EGF) signaling networks can potentiate mitogenic signaling. In HEK293...

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Bibliografiska uppgifter
Huvudupphovsmän: Borisov, Nikolay, Aksamitiene, Edita, Kiyatkin, Anatoly, Legewie, Stefan, Berkhout, Jan, Maiwald, Thomas, Kaimachnikov, Nikolai P, Timmer, Jens, Hoek, Jan B, Kholodenko, Boris N
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683723/
https://ncbi.nlm.nih.gov/pubmed/19357636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2009.19
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