Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge

Influenza prophylaxis would benefit from a simple method to administer influenza vaccine into skin without the need for hypodermic needles. In this study, solid metal microneedle arrays (MNs) were investigated as a system for cutaneous vaccine delivery using influenza virus antigen. The MNs with 5 m...

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Detalhes bibliográficos
Main Authors: Zhu, Qiyun, Zarnitsyn, Vladimir G., Ye, Ling, Wen, Zhiyuan, Gao, Yulong, Pan, Lei, Skountzou, Ioanna, Gill, Harvinder S., Prausnitz, Mark R., Yang, Chinglai, Compans, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683119/
https://ncbi.nlm.nih.gov/pubmed/19416832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812652106
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