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Dystrophin and utrophin have distinct effects on the structural dynamics of actin

We have used time-resolved spectroscopy to investigate the structural dynamics of actin interaction with dystrophin and utrophin in relationship to the pathology of muscular dystrophy. Dystrophin and utrophin bind actin in vitro with similar affinities, but the molecular contacts of these two protei...

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Detalhes bibliográficos
Main Authors: Prochniewicz, Ewa, Henderson, Davin, Ervasti, James M., Thomas, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683112/
https://ncbi.nlm.nih.gov/pubmed/19416869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812007106
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