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Impacts of dystrophin and utrophin domains on actin structural dynamics: implications for therapeutic design
We have used time-resolved phosphorescence anisotropy (TPA) of actin to evaluate domains of dystrophin and utrophin, with implications for gene therapy in muscular dystrophy. Dystrophin and its homolog utrophin bind to cytoskeletal actin to form mechanical linkages that prevent muscular damage. Beca...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367031/ https://ncbi.nlm.nih.gov/pubmed/22504225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.04.005 |
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