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Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
Covalent modification by small ubiquitin-related modifiers (SUMO) regulates p53 transcription activity through an undefined mechanism. Using reconstituted sumoylation components, we purified SUMO-1-conjugated p53 (Su-p53) to near homogeneity. Su-p53 exists in solution as a tetramer and interacts wit...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683057/ https://ncbi.nlm.nih.gov/pubmed/19339993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.83 |
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