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Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

Covalent modification by small ubiquitin-related modifiers (SUMO) regulates p53 transcription activity through an undefined mechanism. Using reconstituted sumoylation components, we purified SUMO-1-conjugated p53 (Su-p53) to near homogeneity. Su-p53 exists in solution as a tetramer and interacts wit...

詳細記述

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書誌詳細
主要な著者: Wu, Shwu-Yuan, Chiang, Cheng-Ming
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683057/
https://ncbi.nlm.nih.gov/pubmed/19339993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.83
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