Interferon Regulatory Factor 1 Binding to p300 Stimulates DNA-Dependent Acetylation of p53

Interferon regulatory factor 1 (IRF-1) and p53 control distinct sets of downstream genes; however, these two antioncogenic transcription factors converge to regulate p21 gene expression and to inhibit tumor formation. Here we investigate the mechanism by which IRF-1 and p53 synergize at the p21 prom...

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Detalhes bibliográficos
Main Authors: Dornan, David, Eckert, Mirjam, Wallace, Maura, Shimizu, Harumi, Ramsay, Eleanor, Hupp, Ted R., Ball, Kathryn L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525491/
https://ncbi.nlm.nih.gov/pubmed/15509808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.22.10083-10098.2004
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